Some fans have noticed that new Scream directors Matt Bettinelli-Olpin and Tyler Gillett have started following Courteney Cox and David Arquette on Twitter. Now, this is in no way a casting announcement. They could simply be following the two because they're fans themselves.
Obviously, take this as a huge grain of salt. Also, did I mention news has been slow? This could all hint that this fifth movie is indeed a follow-up to Scream 4.
There's also a tiny rumor suggesting that Lili Reinhart and Cole Sprouse (of TV's Riverdale) are being eyed for parts in Scream 5...we'll see.